Spin-offs play a crucial role in translating academic research into real-world solutions, but their success in fulfilling their mission depends on more than just great science. This session will discuss the importance and scope of collaborative research agreements between academic players and their spin-offs. How can academic institutions and tech transfer offices provide the right support to ensure long-term growth? What are the common terms set for such collaborative research agreements and why? What common hurdles do spin-offs face, and how can they be addressed? What are the key ingredients to a synergetic relationship between academia and spin-off? How could incubation and funding models adapt to better serve emerging MedTech and digital health companies?